Table 1.

Representative SLC transporter-relevant human diseases.

SLC	Human diseases	Known substrates	References
SLC2A2	T2DM insulin resistance	Facilitated glucose transporter	Dupuis et al. (2010)
SLC16A11	T2DM	Transport of pyruvate across the plasma membrane	Rusu et al. (2017)
SLC30A8	T2DM Insulin resistance	Zinc transporter 8	Dupuis et al. (2010)
SLC6A1	Anxiety disorders	GABA transporter	Thoeringer et al. (2009)
SLC6A12	Schizophrenia in a Korean population	GABA transporter	Park et al. (2011)
SLC6A15	Depression	Branched-chain amino acids, particularly leucine, valine, isoleucine, and methionine	Hyde et al. (2016)
SLC30A10	Neurologic, hepatic, and hematologic disturbances	Manganese transport	Quadri et al. (2012)
SLC24A4	Alzheimer’s disease	Calcium transport	Lambert et al. (2013)
SLC2A9	Gout	Urate	Dehghan et al. (2008); Kolz et al. (2009)
SLC16A9	Gout	Urate	Kolz et al. (2009); Yang et al. (2010)
SLC17A1	Gout	Sodium-dependent phosphate transporter 1; a renal transporter of uric acid	Kolz et al. (2009); Hollis-Moffatt et al. (2012); Nakayama et al. (2017)
SLC17A3	Gout	Urate	Dehghan et al. (2008)
SLC22A11	Gout	Organic anion transporter 4	Yang et al. (2010); Flynn et al. (2013)
SLC22A12	Gout	Urate transporter 1	Kolz et al. (2009); Flynn et al. (2013); Nakayama et al. (2017)
SLC4A7	Elevated blood pressure	Electroneutral Na+/HCO3− cotransporter NBCn1	Lu et al. (2015); Ehret et al. (2016); Wang et al. (2017); Ng et al. (2017)
SLC6A13	Elevated blood pressure chronic kidney disease (CKD)	GABA transporter	Levy et al. (2009); Kottgen et al. (2010); Liu et al. (2011)
SLC8A1	Elevated blood pressure	Sodium(Na+)-calcium(Ca2+) exchanger 1	Warren et al. (2017)
SLC12A1	Blood pressure variation	Kidney-specific sodium–potassium–chloride cotransporter; accounts for most of the NaCl resorption	Ji et al. (2008)
SLC12A3	Blood pressure variation	Renal thiazide-sensitive sodium-chloride cotransporter	Ji et al. (2008)
SLC14A2	Elevated blood pressure	Urea transporter	Warren et al. (2017)
SLC22A4/5	Elevated blood pressure	Gothioneine and carnitine	Wain et al. (2017)
SLC24A3	Elevated blood pressure	K+-dependent Na+/Ca2+ exchanger 3	Warren et al. (2017)
SLC35F1	Elevated blood pressure	Unknown	Warren et al. (2017)
SLC39A8	Elevated blood pressure	Zinc transport	Ehret et al. (2016)
SLC39A13	Elevated blood pressure	Zinc transport	Ehret et al. (2016)
SLC25A32	Blood pressure	Unknown	Fowdar et al. (2017)
SLC7A9	CKD	Transport of cystine and neutral and dibasic amino acids	Kottgen et al. (2010)
SLC34A1	CKD	Sodium–phosphate cotransporter	Kottgen et al. (2010)
SLC22A2	CKD	Metformin, cisplatin, and lamivudine	Kottgen et al. (2010); Liu et al. (2011)
SLC22A5	Asthma	Carnitine transporter	Torgerson et al. (2011); Moffatt et al. (2010)
SLC30A8	Asthma	Zinc transporter 8	Himes et al. (2012)
SLC22A23	Bronchodilator responsiveness in asthma	Unknown	Noguchi et al. (2011)
SLC25A15	Bronchodilator responsiveness in asthma	Unknown	Drake et al. (2014)

For the human SLC family members, Table 1 summarizes their types of predominant transport substrates and links to common diseases (T2DM, depression, Alzheimer’s disease, gout, elevated blood pressure, CKD, and asthma).