Table 3.
Estimated associations between maternal thyroid hormone biomarkers and offspring ADHD or related behaviors.
| Estimated associations between maternal thyroid hormone biomarkers and ADHD or related behaviors | ||
|---|---|---|
| Exposure | Outcome (Time) | Estimate |
| Higher fT4 | ||
| Oostenbroek 201744 | Teacher SDQ hyperactivity/inattention (5 yrs) | OR = 0.95 (0.85, 1.05) |
| Parent SDQ hyperactivity/inattention (5 yrs) | OR = 1.01 (0.90, 1.13) | |
| Chevrier 201151 | ↓ CBCL attention problems (5 yrs) | β = −0.10 (−2.03, 1.82) |
| ↑ KCPT attention problems (5 yrs) | β = 7.52 (−4.86, 19.91) | |
| Andersen 201845 | ADHD prescription (8.4 yrs median) | HR = 1.00 (0.63, 1.59) |
| TPOAb positive | ||
| Ghassabian 201212 | CBCL attention deficit/hyperactivity (3 yrs) | OR = 1.77 (1.15, 2.72) |
| Higher TSH | ||
| Endendijk, 201752 | CBCL attention problems (23-60 mos) | rboys(df=224) = 0.21, p<.01 |
| rgirls NR, not significant | ||
| Oostenbroek 201744 | Teacher SDQ hyperactivity/inattention (5 yrs) | OR = 1.02 (0.96, 1.09) |
| Parent SDQ hyperactivity/inattention (5 yrs) | OR = 1.01 (0.92, 1.11) | |
| Päkkilä 201443 | RB2 inattention & hyperactivity (5 years) | ORboys = 1.17 (1.00, 1.36) |
| ORgirls = 1.39 (1.07, 1.80) | ||
| Chevrier 201151 | ↑ CBCL attention (5 yrs) | β = −0.65 (−1.26, −0.04) |
| ↑ KCPT attention (5 yrs) | β = −0.75 (−4.61, 3.12) | |
| Ghassabian 201113 | CBCL attention deficit/hyperactivity (1.5-3 yrs) | βSD of TSH = 0.08 (0.01, 0.15) |
| Higher TT4 | ||
| Chevrier 201151 | CBCL attention problems (5 yrs) | β = 0.00 (−0.28, 0.27) |
| ↑ KCPT attention problems (5 yrs) | β = 0.09 (−1.70, 1.87) | |
Abbreviations: ADHD = Attention Deficit Hyperactivity Disorder, CBCL = Child Behavior Checklist, mos = months, HR = Hazard ratio, KCPT = Conners Kiddie Continuous Performance Test, OR = Odds ratio, RB2 = Rutter B2 Scale – Finnish Version, SDQ = Strengths and Difficulties Questionnaire, TPOAb = Thyroid peroxidase antibodies, TSH = Thyroid stimulating hormone, TT4 = Total thyroxin, yrs = years