Table 4.
Studies of ADHD related behaviors among children with early-treated congenital hypothyroidism.
| First Author, Year Country |
Study Design (Sample Size) | Thyroid Function Measurement (Timing) | Outcome Measurement (Timing) | Adjustment Set a |
|---|---|---|---|---|
|
Kooistra, 200456 The Netherlands |
Cohorts selected based on congenital hypothyroidism status (Ntotal = 82) | Congenital hypothyroidism (birth) | Memory search task based on Sternberg response bias task (7.0–8.8 yrs) | 4 |
|
Kooistra, 200157 The Netherlands |
Cohorts selected based on congenital hypothyroidism status (Ntotal = 97) | Congenital hypothyroidism (birth) | Groningen Behavior Checklist School and Family Situation (7.5, 9.5 yrs) | None |
|
Kooistra, 199658 The Netherlands |
Cohorts selected based on congenital hypothyroidism status (Ntotal = 83) | Congenital hypothyroidism (birth) | Computer-paced continuous performance task, self-paced performance task (7.0-8.75 yrs) | 4 |
|
Rovet, 2001a (Attention…)53
Canada |
Retrospective cohort selected based on congenital hypothyroidism status (Ntotal = 98) | Congenital hypothyroidism (birth) | Child Behavior Checklist (filled out by parents), Battery of Behavioral Attention Tests (12.6-15.2 yrs) |
1 |
|
Rovet, 2001b (Dissociating…)54 Canada |
Retrospective cohort selected based on congenital hypothyroidism status (Ntotal = 144) | Congenital hypothyroidism, TSH, T4 (birth) | Two versions of Connors’ Continuous Performance Task (7-12 yrs) | 1, 2, 3, 4 |
|
Rovet, 199955 Canada |
Retrospective cohort selected based on congenital hypothyroidism status (Ntotal = 118) | Congenital hypothyroidism, T4 (birth) | Psychometric instruments including, but not limited to, Griffiths Test, Bayley Test, McCarthy Test, and the Wechsler Intelligence Scale for Children III (13 yrs) | None |
|
Tinelli, 200314 Italy |
Cohorts selected based on congenital hypothyroidism status (Ntotal = 146) | Congenital hypothyroidism (birth) | Child Behavior Checklist filled out by parents (10 and 13 years) | None |
Key for adjustment set: 1 = child age/bone age at testing; 2 = child sex; 3 = SES; 4 = child IQ.
Abbreviations: ADHD = Attention Deficit Hyperactivity Disorder, T4 = thyroxine, TSH = thyroid stimulating hormone, yrs = years.
a
The adjustment set includes variables that were statistically controlled for in analyses included in this review, or were assessed as potential covariates for analyses included in this review, as well as exclusion or restriction factors that were relevant for this review.