Table 3.

Summary of cases receiving molecular diagnosis with exome as first-tier or second-tier testing

	Patient age at testing (days) median±sem	Exome TAT (days) median±sem	Patient age at diagnosis (days) median±sem	Clinical management changed (number and percentage)	Exome category (number and percentage)
Exome offered as first-tier testing 56/102 (54.9%)	13.7±3.9	38.4±4.7	70.8±20.6	30/56 (53.6%)	Proband: 25/56 (44.6%) Trio: 7/56 (12.5%) Critical: 24/56 (42.9%)
Exome offered as second-tier testing 46/102 (45.1%)	36.6±4.4	73.0±5.1	123.6±37.6	23/46 (50.0%)	Proband: 33/46 (71.7%) Trio: 5/46 (10.8%) Critical: 8/46 (17.4%)
p value (two-tailed t-test)	0.004904	0.001013	0.007907	0.842402	N/A

sem: standard error of mean

N/A: not applicable