Table 5.

Consistent directions of associations across CpG methylation, gene expression and EOC risk for 12 CpGs and five genes

CpG	Chr	Position	Gene	Classification	CpG Vs. EOC risk		CpG Vs. Gex b		Gex bVs. EOC risk		Adjusted a Gex Vs. EOC risk
					Dir b	P value	Dir b	P value	Dir b	P value	Dir	P value
cg18878992	17	43,974,344	MAPT	5'UTR	+	8.85×10−13	−	2.64×10−3	−	3.74×10−4	−	0.48
cg00480298	17	44,068,857	MAPT	Exonic	+	6.39×10−9	−	3.98×10−3	−	3.74×10−4	−	0.65
cg07368061	17	44,090,862	MAPT	Intronic	−	4.26×10−13	+	2.02×10−3	−	3.74×10−4	−	1.00
cg01572694	17	46,657,555	HOXB3	Intronic	−	5.52×10−9	+	7.49×10−3	−	2.00×10−7	−	0.82
cg14285150	17	46,659,019	HOXB3	Intronic	−	5.53×10−8	+	8.44×10−5	−	2.00×10−7	−	0.51
cg24672833	17	46,659,318	HOXB3	Intronic	−	9.00×10−8	+	5.51×10−3	−	2.00×10−7	−	0.41
cg17941109	19	17,407,198	ABHD8	Intronic	−	2.88×10−9	−	0.03	+	9.93×10−6	−	0.57
cg19139618	17	46,504,791	SKAP1	Intronic	−	7.08×10−7	−	2.98×10−15	+	NA c
cg02957270	17	46,508,097	SKAP1	TSS1500	+	4.40×10−12	+	0.01	+
cg07067577	17	43,506,829	ARHGAP27	3'UTR	−	6.86×10−14	−	1.20×10−3	+	NA c
cg16281322	17	43,510,478	ARHGAP27	TSS200	−	6.82×10−13	−	1.14×10−9	+
cg25708777	17	43,510,841	ARHGAP27	TSS1500	−	4.61×10−13	−	4.11×10−8	+

^aAdjusting for all the predicting SNPs included in prediction models of corresponding CpGs

^bDir, direction of association/correlation; Gex, gene expression

^cSKAP1 and ARHGAP27 are previously identified EOC-susceptibility genes.