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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Cancer Immunol Res. 2018 Dec 18;7(2):230–243. doi: 10.1158/2326-6066.CIR-18-0266

Figure 4: Effects of pharmacological modification of histone-associated proteins identified by CoGAPS gene expression analysis on ADCC sensitivity.

Figure 4:

A, Western blot of PCAF (KAT2B) in ADCCS1 and ADCCR1 cells. ADCCS1 and ADCCR1 cells post 33 challenges passaged for 3-4 times were used. Densitometry values of expression relative to GAPDH indicated below. B, Specific lysis of ADCCS1 (blue) and ADCCR1 (red) measured by ADCC assay at 4 hrs when pre-treated with increasing concentrations of histone acetyl transferase inhibitor (HATi) C646 for 2 hours. C, Specific lysis of ADCCS1 (blue) and ADCCR1 (red) measured by ADCC assay at 4 hrs when pre-treated with increasing concentrations of DNMT (DNMTi), pan-HDAC (pan-HDACi), and histone demethylase inhibitors.