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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Mol Cancer Res. 2018 Oct 24;17(2):457–468. doi: 10.1158/1541-7786.MCR-18-0946

Figure 4: Metastasis enrichment for ESR1 amplifications in validation datasets.

Figure 4:

A. Barplot for the percentage of ESR1 amplifications in three different genomic datasets (grey, primary; black, metastasis). Actual counts for amplified samples are indicated within each bar, with p values for metastatic enrichment on top. AACR, American Association for Cancer Research; MSKCC, Memorial Sloan Kettering Cancer Center; FM, Foundation Medicine. MSKCC is also a major contributor to the AACR_GENIE dataset. (For the FM dataset, samples denoted as “Primary” tumors can contain local recurrences since disease is defined by the site of biopsy). B. Kaplan-Meier curves for MSKCC survival data grouped by ESR1 CN status for patients with metastastic breast cancer.