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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Drug Dev Res. 2018 Aug 2;80(1):48–67. doi: 10.1002/ddr.21453

Table 3.

Reports of the in vivo use of aBL in animal models of localized infection

Light Source Animal model Bacterial species/strains Inactivation efficacy  Ref
405–425 nm LED Infected skin abrasion on mouse back Bioluminescent MRSA
USA300LAC::lux		 > 2 log10 reduction of bioluminescence after 40 J/cm2 (day 0) or 108 J/cm2 (day 1) Dai et al (88)
405–425 nm LED Infected 3rd degree burn on mouse back Bioluminescent P. aeruginosa Bioluminescence was reduced 100-fold by 55 J/cm2. Mouse survival was 100% vs 18.2% in untreated mice Dai et al (89)
405–425 nm LED Infected 3rd degree burn on mouse back Bioluminescent A. baumannii 55.8 J/cm2 reduced bacterial levels in burn Zhang et al (90)
405–425 nm LED Infected 3rd degree burn on mouse back Bioluminescent C. albicansi A single exposure of 432 J/cm2 aBL reduced the fungal burden in infected mouse burns by 1.75-log10 Zhang et al (91)
405–425 nm LED Infectious keratitis in mice Bioluminescent P. aeruginosa Bacterial luminescence in the infected corneas was reduced (>2-log10) after a single exposure of aBL. Zhu et al (92)