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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: J Mol Cell Cardiol. 2019 Jan 3;127:232–245. doi: 10.1016/j.yjmcc.2018.12.016

Figure 5: LGM2605 increases mitochondrial calcium uptake in isolated primary cardiomyocytes from septic mice –

Figure 5:

(A-C) Mitochondrial calcium uptake after a single bolus of calcium in permeabilized adult cardiomyocytes isolated from mice at 12 h post-CLP or control sham surgery; n=3 mice per group. #P<0.05 vs CLP; Kruskall-Wallis test with Dunn’s multiple comparisons. (D) MCU, MICU1 gene expression from ventricular tissue of mice 12 h after sham surgery, CLP with or without treatment with LGM2605 at 6 h post-CLP, n=4–5 mice. (E) Immunoblots and densitometric analysis of cardiac MCU, MICU1 normalized with ATP5A 12 h after