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. 2019 Jan 16;2019:8148510. doi: 10.1155/2019/8148510

Figure 4.

Figure 4

Curcumin suppressed HSC-induced invasion in HepG2 cells through decreasing HIF-1α. St Med stands for standard media of HepG2 cells, CM stands for conditioned media from HSCs, CM + Cur stands for conditioned media from HSCs with curcumin exposure, CM + NAC stands for conditioned media from HSCs with NAC exposure, sh-HIF-1α-CM + Cur stands for sh-HIF-1α knockdown HepG2 cells treated with conditioned media from HSCs pretreated with curcumin, sh-HIF-1α-CM + NAC stands for sh-HIF-1α knockdown HepG2 cells treated with conditioned media from HSCs pretreated with NAC, and sh-HIF-1α-CM stands for sh-HIF-1α knockdown HepG2 cells treated with conditioned media from HSCs. The cells were placed in a Matrigel-coated invasion chamber for 20 h. (a, b) We evaluated invasion ability by counting the numbers of migrated cells in ten randomly selected fields under a light microscope at ×100 magnification. ∗p < 0.05 versus St Med group (n = 6), #p < 0.05 versus CM (n = 6). All data are representative of at least three independent experiments.