Figure 6.

Nrf2 and GSH participate in curcumin-induced HCC protection. (a) HepG2 cells were silenced by control shRNA (sh-control), shRNA targeting HIF-1α (sh-HIF-1α), or shRNA targeting CTGF (sh-CTGF); nuclear Nrf2 protein levels of HepG2 cells were analyzed by western blot. (b) Glutathione (GSH) and glutathione disulfide (GSSG) levels were evaluated in HepG2 cells. ^∗p < 0.05 versus St Med group (n = 3), ^#p < 0.05 versus CM (n = 3). All data are representative of at least three independent experiments.