Figure 2.

The precision therapy paradigm. Successful application of the concept of precision medicine relies on the ability to identify constantly evolving molecular aberrations that occur in response to treatment and as a result of the passage of time. The initial step in this process is to obtain sufficient tissue at the time of diagnosis for molecular profiling and identification of targets for precision therapy. The initial choice of systemic therapy should be based on the presence of a druggable target. Upon disease progression, attempts should be made to acquire tumor tissue from the sites of progression to perform molecular analyses and determine the cause of treatment failure.