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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Bone. 2018 Nov 5;120:212–218. doi: 10.1016/j.bone.2018.11.002

Table 1.

Muscle to Bone Crosstalk

Myostatin Deletion results in animals with enlarged muscles and larger bones. Inhibitor of osteoblast differentiation and promoter of osteoclast activation. Buerhing, 2013[73]
Irisin May support or inhibit bone formation Kim 2018 [36]
β-aminoisobutyric acid, BAIBA Prevents osteocyte cell death, preserves bone and muscle Kitase, 2018[24]
Brain-Derived Neurotrophic Factor, BDNF Regulates VEGF secretion by osteoblasts Zhang, 2017 [74]
Interleukin 6, Il-6 Increases osteoclasts Kurihara 1990[75]
IL-15 Supports osteoblastic matrix formation Loro, 2017[76]
Il-7 promotes osteoclastogenesis Weitzmann 2000[77]