Table 2:

Disease Free Survival Analysis

	DFS Events/N	DFS KM 2 Year Estimate (95% CI)	DFS ^a HR (95% CI)
Arm: OPEN	56/222	83.2 (78.3, 88.3)	Ref
LAP	56/240	79.5 (74.4, 84.9)	0.95 (0.65, 1.37)
Composite Score: Successful	86/389	82.9 (79.2, 86.8)	Ref
Unsuccessful resection	26/73	69.1 (59, 81.1)	1.87 (1.21, 2.91)
Distal Margin: Negative	108/454	81.6 (78, 85.3)	Ref
Positive	4/8	46.9 (21.5, 100)	2.53 (0.93, 6.86)
Circumferential Margin: > 1mm	93/416	83.2 (79.6, 87)	Ref
≤ 1 mm	19/46	61 (48.1, 77.5)	2.31 (1.40, 3.79)
Completeness of TME: Complete	83/356	82.7 (78.8, 86.8)	Ref
Nearly complete	19/76	75.6 (66.4, 86.1)	1.15 (0.70, 1.90)
Incomplete	10/30	73.9 (58.9, 92.7)	1.65 (0.85, 3.18)
Rectal Perforation: No	93/404	82.7 (79.1, 86.6)	Ref
Yes	19/58	70.7 (59.6, 83.9)	1.65 (1.00, 2.71)
Surgical approach: LAR	23/142	86.7 (81.2, 92.6)	Ref
LAR + Coloanal Anastomosis	52/206	81.7 (76.5, 87.2)	1.52 (0.93, 2.48)
Abdominal Perineal Resection	33/105	72.4 (64, 81.9)	2.21 (1.30, 3.77)
Location of tumor in rectum:
Other (Top, High)	48/233	83 (78.2, 88.1)	Ref
Low	64/229	79.4 (74.2, 85)	1.38 (0.95, 2.0)
Tumor distance from anal verge (cm)^b	~	~	0.94 (0.89, 1.00)
Tumor size, largest dimension (cm)^c	~	~	1.03 (0.95, 1.13)

Abbreviations: DFS, Disease Free Survival; KM, Kaplan Meier; TME, Total Mesorectal Excision; LAR, Lower Anterior Resection

– CoxPH model adjusted by arm reflecting Hazard Ratio and 95% Confidence Interval.

– Missing tumor distance for 3 patients (2 LAP).

– Missing tumor size for 15 patients (9 LAP).