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. Author manuscript; available in PMC: 2019 Nov 28.
Published in final edited form as: Chem Rev. 2018 Oct 29;118(22):10840–11022. doi: 10.1021/acs.chemrev.8b00074

Figure 10.

Figure 10.

Active site structure of an oxy form of HO bearing the heme with axially coordinated His20, “distal” (yellow), and “proximal” (green) helices, and the critical water cluster held in place by Asp136. See the text for further discussion.