Skip to main content
. Author manuscript; available in PMC: 2019 Nov 28.
Published in final edited form as: Chem Rev. 2018 Oct 29;118(22):10840ā€“11022. doi: 10.1021/acs.chemrev.8b00074

Figure 135.

Figure 135.

(Top) Evaluated mechanistic pathways for the reaction of a heme-peroxo-copper complex, LS-AN, with 4-OMe-phenol which proceed through one of two transition states, denoted TSpi for the proton-initiated mechanism and TShb for the hydrogen bond assisted pathway (see text for discussion). (Bottom) The potential energy surfaces for the PI and HB pathways. The red and blue lines in each plot correspond to the progress of the reaction leading to the products shown in the top, right, with the highest point on each surface being the transition state for each reaction. Dashed lines denote where the pathway is behind the surface. Adapted from ref 747. Copyright 2017 American Chemical Society.