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. Author manuscript; available in PMC: 2019 Nov 28.
Published in final edited form as: Chem Rev. 2018 Oct 29;118(22):10840–11022. doi: 10.1021/acs.chemrev.8b00074

Figure 144.

Figure 144.

(Top) (A) Heme a3/CuB site of bovine CcO and (B) overlaid structural models of imiTyrCuBMb (green) containing the imidazole-phenol cross-linked, imiTyr, and F33YCuBMb (gray) which contains non-cross-linked His and Tyr residues proximal to the CuB site. (Bottom) (C) Rate of O2 consumption to yield water or ROS (superoxide, peroxide) in the reactions of WT-Mb and the two different mutants shown in (B), each with and without CuII in the Cub site. Conditions: [Mb variant] = 6 μM; [TMPD] = 0.6 mM; [ascorbic acid] = 6 mM. Adapted with permission from ref 1108. Copyright 2012 Wiley-VCH.