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. Author manuscript; available in PMC: 2019 Nov 28.
Published in final edited form as: Chem Rev. 2018 Oct 29;118(22):10840ā€“11022. doi: 10.1021/acs.chemrev.8b00074

Figure 145.

Figure 145.

(Left) Crystal structure of the Phe33Tyr-CuBMb variant (PDB ID: 4FWX) and the pKa values of Tyr and its non-natural mimics which can be substituted in the 33rd position. (Right) Plots showing the linear correlations between the Mb variants with various Tyr33 analogs and their O2-reduction activity (top) or water production (middle) as a function of phenol moiety pKa, and O2-reduction activity as a function of phenol peak potential, Ep at pH = 13 (bottom). Adapted from ref 1119. Copyright 2015 American Chemical Society.