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. Author manuscript; available in PMC: 2019 Nov 28.
Published in final edited form as: Chem Rev. 2018 Oct 29;118(22):10840ā€“11022. doi: 10.1021/acs.chemrev.8b00074

Scheme 3.

Scheme 3.

Previously Proposed Base (B) Catalyzed Activation of Indoles with Oxy-Heme Species Forming a Peroxyindole Intermediate, Which Reacts Further by Either Criegee (maroon) or Dioxetane (green) Pathwaysa

a Adapted from ref 211. Copyright 2011 American Chemical Society.