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. Author manuscript; available in PMC: 2019 Nov 28.
Published in final edited form as: Chem Rev. 2018 Oct 29;118(22):10840ā€“11022. doi: 10.1021/acs.chemrev.8b00074

Scheme 22.

Scheme 22.

Supposed Mechanisms of His-Tyr Crosslink Biogenesis in the (A) Presence or (B) Absence of O2a

aAdapted with permission from ref 612. Copyright 2016 Springer. Other reaction sequences to effect oxidative cross-coupling of His and Tyr residues can be envisioned.