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. 2019 Jan 28;9:748. doi: 10.3389/fgene.2018.00748

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Copyright © 2019 Zhu, Li, Li, Zhu and Xiong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Light microscopy. (A) Focal segmental glomeruosclerosis (x400, PAS.). One segmental sclerosis with top adhesion (black arrow). (B) Diffuse vacuolar degeneration (black arrows) of the GBM (x600, PASM+Masson.). Immunofluorescence. The α3 and α5 chains are distributed in the GBM (x600). (C) α3 chain. (D) α5 chain. Electron microscopy. (E) The thickness of GBM is different and the density is uneven (black arrow). Green Pentagram shows mesangium and mesangial cells. (F) The mesangial insertion can be seen in a few of segments, and the dense layer of GBM is tearing and stratified (black arrow).