Table 2.

Survival analyses results of coagulation factors

Variables	Unadjusted HR (95% CI)	P	Adjusted HR (95% CI) model 1†	P	Adjusted HR (95% CI) model 2‡	P
D‐D§
≤ 0.20 mg/L	‐Reference‐	—	‐Reference‐	—	‐Reference‐	—
> 0.20 mg/L	2.25 (0.96–5.26)	0.06	1.86 (0.75–4.60)	0.18	1.61 (0.66–3.93)	0.30
FIB§
≤ 2.75 g/L	‐Reference‐	—	‐Reference‐	—	‐Reference‐	—
> 2.75 g/L	3.82 (1.43–10.23)	< 0.01	2.23 (0.76–6.54)	0.14	1.79 (0.59–5.43)	0.31
PLT§
≤ 215 × 109/L	‐Reference‐	—	‐Reference‐	—	‐Reference‐	—
> 215 × 109/L	2.69 (1.11–6.48)	0.03	2.32 (0.95–5.70)	0.07	2.42 (0.98–5.95)	0.05
PLT, FIB, and D‐D score
Every one point increase	2.24 (1.41–3.56)	< 0.001 ¶	1.89 (1.14–3.16)	0.01 ¶	1.76 (1.05–2.94)	0.03 ¶
PLT, FIB, and D‐D score
Score 0 or 1	‐Reference‐	—	‐Reference‐	—	‐Reference‐	—
Score 2 or 3	7.54 (2.25–25.27)	< 0.01	4.71 (1.34–16.52)	0.02	4.62 (1.29–16.51)	0.02

^† Model 1: single‐level multivariate model; adjusted for gender, anatomic location, lymphovascular invasion (LVI), visceral pleural invasion (VPI), tumor node metastasis (TNM) stage, and tumor size.

^‡ Model 2: multilevel model; adjusted for gender, anatomic location, LVI, VPI, TNM stage, and tumor size.

^§ Preoperative levels, missing values were imputed using Markov chain Monte Carlo.

^¶ P value for trend. Bold values (P<0.05) indicate statistical significance. CI, confidence interval; D‐D, D‐dimer; FIB, fibrinogen; HR, hazard ratio; PLT, platelet.