Table 3.
Survival analyses results of clinicopathological and other factors
| Variables | Unadjusted HR (95% CI) | P | Adjusted HR (95% CI)† | P | Adjusted HR (95% CI)‡ | P |
|---|---|---|---|---|---|---|
| Gender | ||||||
| Male | ‐Reference‐ | — | ‐Reference‐ | — | ‐Reference‐ | — |
| Female | 0.28 (0.10–0.82) | 0.02 | 0.53 (0.16–1.71) | 0.29 | 0.46 (0.14–1.55) | 0.46 |
| TNM stage | ||||||
| Stage I–II | ‐Reference‐ | — | ‐Reference‐ | — | ‐Reference‐ | — |
| Stage III | 7.93 (3.55–17.73) | < 0.001 | 5.48 (2.06–14.55) | < 0.001 | 4.76 (1.81–12.51) | < 0.01 |
| Anatomic location | ||||||
| Central type | ‐Reference‐ | — | ‐Reference‐ | — | ‐Reference‐ | — |
| Peripheral type | 0.22 (0.10–0.50) | < 0.001 | 0.69 (0.27–1.77) | 0.43 | 0.89 (0.34–2.36) | 0.82 |
| LVI | ||||||
| Yes | ‐Reference‐ | — | ‐Reference‐ | — | ‐Reference‐ | — |
| No | 0.31 (0.12–0.79) | 0.01 | 1.31 (0.44–3.88) | 0.63 | 1.07 (0.34–3.32) | 0.91 |
| VPI | ||||||
| Yes | ‐Reference‐ | — | ‐Reference‐ | — | ‐Reference‐ | — |
| No | 0.37 (0.16–0.87) | 0.02 | 1.11 (0.44–2.82) | 0.83 | 1.47 (0.54–4.02) | 0.45 |
| Tumor size | 1.35 (1.17–1.56)§ | < 0.001 | 1.11 (0.91–1.35)§ | 0.31 | 1.08 (0.87–1.34)§ | 0.49 |
| Hospital& | Adjusted hazard (95% CI) ¶ | |||||
| Hospital 1 | — | — | — | — | 1.15 (0.35–3.78) | 0.82 |
| Hospital 2 | — | — | — | — | 0.93 (0.24–3.54) | 0.91 |
| Hospital 3 | — | — | — | — | 0.58 (0.11–3.02) | 0.51 |
| Hospital 4 | — | — | — | — | 0.34 (0.08–1.49) | 0.15 |
| Hospital 5 | — | — | — | — | 0.74 (0.12–4.36) | 0.74 |
| Hospital 6 | — | — | — | — | 3.67 (1.26–10.66) | 0.02 |
| Hospital 7 | — | — | — | — | 1.80 (0.49–6.60) | 0.38 |
Only the variables that were statistically significant in univariate analyses were included in multivariate and multilevel analyses.
Single‐level multivariate model; adjusted for each other and platelet (PLT), fibrinogen (FIB), and D‐dimer (D‐D) score as a binary variable.
Multilevel model; adjusted for each other and PLT, FIB, and D‐D score as a binary variable.
Hazard ratio (HR) for every one unit increase in the variable.
Exponential of the random intercept in multilevel model; gender, tumor node metastasis (TNM) stage, anatomic location, lymphovascular invasion (LVI), visceral pleural invasion (VPI), tumor size and PLT, FIB and D‐D score (binary variable) were adjusted.
Bold values (P<0.05) indicate statistical significance. CI, confidence interval.