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. 2019 Jan 3;10(2):277–288. doi: 10.1111/1759-7714.12947

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© 2019 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Inhibition of cancer‐derived Type I collagen suppressed tumor clone formation while increasing the invasive ability of cancer cells. (a,b) Wound‐healing assays show that cell motility and invasion were markedly increased in an A549 cell line treated with a Type I collagen inhibitor. Representative images were taken at 0, 24, and 48 hours after scratching. (c, top) After Type I collagen was inhibited, a significant reduction in the number of tumor clones was observed on the culture dishes, indicating that the Type I collagen inhibitor significantly suppressed tumor clone formation. (c, bottom) Cancer cell invasion was also promoted when Type I collagen was inhibited. The results are presented as the mean ± standard deviation. (d) Column charts of the statistical results (P, *< 0.05, **< 0.01). Control, C inhibitor.

Inline graphic — Inhibition of cancer‐derived Type I collagen suppressed tumor clone formation while increasing the invasive ability of cancer cells. (a,b) Wound‐healing assays show that cell motility and invasion were markedly increased in an A549 cell line treated with a Type I collagen inhibitor. Representative images were taken at 0, 24, and 48 hours after scratching. (c, top) After Type I collagen was inhibited, a significant reduction in the number of tumor clones was observed on the culture dishes, indicating that the Type I collagen inhibitor significantly suppressed tumor clone formation. (c, bottom) Cancer cell invasion was also promoted when Type I collagen was inhibited. The results are presented as the mean ± standard deviation. (d) Column charts of the statistical results (P, *< 0.05, **< 0.01). Control, C inhibitor.