Table 1.
FAN1 expression is associated with slowed HD progression and delayed AAO
| ID | CHR | Pos (Mb) | TWAS.Z (GeM) | TWAS.P (GeM) | TWAS.Z (track +registry) | TWAS.P (track +registry) |
|---|---|---|---|---|---|---|
| OCA2 | 15 | 28.0 | 0.97 | 3.30E-01 | 1.19 | 2.34E-01 |
| HERC2 | 15 | 28.4 | 0.85 | 3.95E-01 | 2.70 | 6.90E-03 |
| HERC2P9 | 15 | 28.9 | −1.21 | 2.28E-01 | 1.13 | 2.59E-01 |
| NDNL2 | 15 | 29.6 | 0.07 | 9.41E-01 | 1.09 | 2.76E-01 |
| FAN1 | 15 | 31.2 | 6.99 | 2.80E-12 | −3.78 | 1.58E-04 |
| CHRNA7 | 15 | 32.3 | 0.10 | 9.20E-01 | −0.01 | 9.93E-01 |
| ARHGAP11A | 15 | 32.9 | −1.49 | 1.35E-01 | 0.10 | 9.21E-01 |
| GREM1 | 15 | 33.0 | −0.74 | 4.62E-01 | −0.25 | 8.01E-01 |
| AVEN | 15 | 34.2 | −0.48 | 6.28E-01 | 0.17 | 8.67E-01 |
| CHRM5 | 15 | 34.3 | 0.84 | 4.03E-01 | −1.35 | 1.78E-01 |
| SLC12A6 | 15 | 34.5 | 0.77 | 4.43E-01 | 1.57 | 1.16E-01 |
| NOP10 | 15 | 34.6 | −0.29 | 7.74E-01 | −1.35 | 1.78E-01 |
| GOLGA8A | 15 | 34.7 | 1.66 | 9.75E-02 | −0.56 | 5.75E-01 |
| GOLGA8B | 15 | 34.8 | 0.46 | 6.49E-01 | 0.64 | 5.24E-01 |
| AQR | 15 | 35.1 | 1.01 | 3.13E-01 | −1.76 | 7.92E-02 |
| ZNF770 | 15 | 35.3 | 0.93 | 3.54E-01 | −0.26 | 7.92E-01 |
TWAS results from a 5 Mb either side of FAN1 using predictors derived from Common Mind Consortium prefrontal cortex expression data applied to summary statistics from the GeM study of AAO and the TRACK+REGISTRY study of progression. Positive Z-scores indicate that increased expression associates with later AAO (GeM) or faster progression. Genes with nominally significant TWAS association are highlighted in red.