Table 3.
The expression of the identified transcription factors in HSV-1 or HSV-2 infected tissues
| Tissue type | HSV1 | HSV2 | Oct-1 | Myb | Pax-6 | Hairy | TF Function | Ref. |
|---|---|---|---|---|---|---|---|---|
| Brain: Human glioblastoma cells, brain | HSV1-F | — | — | B-Myb | — | — | activate/γ34.5 | 32 |
| Urinary: Human PDAC-derived Capan-2 cells, BxPC-3, pancreatic, | HSV1-F | — | — | Myb | — | — | suppress/ICP6 | 33 |
| Colon: Human HT29 carcinoma cells, | HSV1-F | — | — | Myb | — | — | activate /γ34.5 | 34 |
| Embryonic: WT and dOct MEF cells | HSV1-F | — | Oct-1 | — | — | — | activate/VP16 | 35 |
| Genital: HeLa cells | HSV1-F | — | Oct-1 | — | — | — | not described | 27 |
| Digestive: Hep2 cells | HSV-1 KOS | — | Oct-1 | — | — | — | activate /VP16 | 36 |
| Genital: HeLa cells | HSV-1 KOS | — | Oct-1 | — | — | — | activate /VP16 | 37 |
| Urinary: COS-7 cells | HSV-1 KOS | — | Oct-1 | — | — | — | activate /VP16 | 38 |
| Genital: HFF | HSV-1 KOS | — | Oct-1 | — | — | — | activate /VP16 | 39 |
PDAC: pancreatic ductal adenocarcinoma; MEF: mouse embryonic fibroblas; HFF: human foreskin fibroblast. COS-7: are fibroblast-like cell lines derived from monkey kidney tissue.