Table 4.
Frequency distributions of the combined genotypes of rs1136201 and rs1058808 polymorphisms among the cases and controls, and their correlation to risk of cervical cancer
| Genotype | Cases (n=413) | Controls (n=396) | Pa | Adjusted OR (95%CI)b | |||
|---|---|---|---|---|---|---|---|
| n | % | n | % | ||||
| Number of risk allelesc | |||||||
| 0 | 42 | 10.17 | 52 | 13.13 | 0.012 | 1.00 (Ref.) | |
| 1 | 105 | 25.42 | 121 | 30.56 | 1.22 (0.60-2.46) | ||
| 2 | 161 | 38.98 | 159 | 40.15 | 1.52 (0.78-2.97) | ||
| 3 | 93 | 22.52 | 58 | 14.65 | 2.23 (1.02-4.91) | ||
| 4 | 12 | 2.91 | 6 | 1.52 | 4.48 (0.94-21.29) | ||
| P trend | 0.002 | ||||||
| Recombined groupsc | |||||||
| 0-2 | 308 | 74.58 | 332 | 83.84 | 1.00 (Ref.) | ||
| 3-4 | 105 | 25.42 | 64 | 16.16 | 0.028 | 1.70 (1.06-2.74) | |
a two-side chi-square test. b Adjusted for age, age at menarche, age at menopause, age at first live birth, smoking status, menopausal status, parity and family history of cancer. c The 0-4 represents the numbers of risk alleles within the combined genotypes; the risk alleles used for the calculation were the rs1136201 G and rs1058808 G alleles.