Table 1.
Functional enrichment analysis of aberrantly methylated-DEGs in HCC.
| Category GO analysis |
Terms | count | P value |
|---|---|---|---|
| Hypomethylation and high expression | |||
| GOTERM_BP_FAT | GO:0000278~ mitotic nuclear division | 11 | 7.9E-5 |
| GOTERM_BP_FAT | GO:0007062~ sister chromatid cohesion | 7 | 3.2E-4 |
| GOTERM_BP_FAT | GO:0007059~ chromosome segregation | 6 | 3.5E-4 |
| GOTERM_BP_FAT | GO:0032212~ positive regulation of telomere maintenance via telomerase and apoptotic process and cell cycle | 4 | 2.9E-3 |
| GOTERM_BP_FAT | GO:0007049~ cell cycle | 8 | 3.4E-3 |
| GOTERM_CC_FAT | GO:0005829~ cytosol | 58 | 3.1E-8 |
| GOTERM_CC_FAT | GO:0070062~ extrocellular | 50 | 3.1E-7 |
| GOTERM_CC_FAT | GO:0005737~ cytoplasm | 72 | 4.0E-6 |
| GOTERM_CC_FAT | GO:0005925~ focal adhesion | 14 | 3.1E-5 |
| GOTERM_CC_FAT | GO:0005654~ nucleuplasm | 40 | 8.9E-4 |
| GOTERM_MF_FAT | GO:0005515~ protein binding | 101 | 7.8E-4 |
| GOTERM_MF_FAT | GO:0005178~ integrin binding | 6 | 2.7E-3 |
| GOTERM_MF_FAT | GO:0004672~ protein kinase activity | 9 | 1.7E-2 |
| GOTERM_MF_FAT | GO:0055100~ adiponectin binding | 2 | 2.7E-2 |
| GOTERM_MF_FAT | GO:0019888~ protein phosphatase regulatory activity | 3 | 2.9E-2 |
| Hypermethylation and expression | |||
| GOTERM_BP_FAT | GO:0050885~ neuromuscular process controlling balance | 5 | 4.1E-4 |
| GOTERM_BP_FAT | GO:0032496~ response to lipopolysaccharide | 7 | 1.6E-3 |
| GOTERM_BP_FAT | GO:0001960~ negative regulation of cytokine-mediated signaling pathway | 3 | 2.0E-3 |
| GOTERM_BP_FAT | GO:0007165~ signal transduction | 19 | 3.1E-3 |
| GOTERM_BP_FAT | GO:0007204~ positive regulation of cytosolic calcium ion concentration | 6 | 3.6E-3 |
| GOTERM_CC_FAT | GO:0005887~ integral component of plasma membrane | 25 | 7.3E-5 |
| GOTERM_CC_FAT | GO:0005578~ proteinaceous extracellular matrix | 10 | 1.5E-4 |
| GOTERM_CC_FAT | GO:0005615~ extracellular space | 19 | 8.4E-3 |
| GOTERM_CC_FAT | GO:0005886~ plasma membrane | 43 | 9.2E-3 |
| GOTERM_CC_FAT | GO:0030426~ growth cone | 5 | 1.0E-2 |
| GOTERM_MF_FAT | GO:0005201~ extracellular matrix structural constituent | 5 | 1.7E-3 |
| GOTERM_MF_FAT | GO:0020037~ heme binding | 6 | 4.0E-3 |
| GOTERM_MF_FAT | GO:0019825~ oxygen binding | 4 | 5.5E-3 |
| GOTERM_MF_FAT | GO:0004601~ peroxidase activity | 3 | 1.2E-2 |
| GOTERM_MF_FAT | GO:0008236~ serine-type peptidase activity | 4 | 1.2E-2 |