Table 3.
Univariate analysis of preoperative variables prognostic for PCa and its bone metastases.
| PCa vs BPH | Bone metastases vs Without bone metastases | |||||
|---|---|---|---|---|---|---|
| Variables | HR (95%CI) | p value | Variables | HR (95%CI) | p value | |
| Age | 1.011 (0.987~1.103) | 0.351 | Age | 0.999 (0.956~1.045) | 0.974 | |
| AKP | 1.016 (1.006~1.025) | 0.001 | AKP | 1.042 (1.025~1.058) | 0.000 | |
| LDH | 1.002 (0.999~1.006) | 0.230 | LDH | 1.016 (1.008~1.025) | 0.000 | |
| FIB | 1.205 (0.974~1.491) | 0.086 | FIB | 1.521 (1.132~2.042) | 0.005 | |
| PSA | 1.058 (1.036~1.080) | 0.000 | PSA | 1.006 (1.003~1.008) | 0.000 | |
| PV | 0.990 (0.985~0.995) | 0.000 | PV | 1.000 (0.996~1.003) | 0.788 | |
| Pathological grade High vs Low |
4.904 (2.076~11.582) | 0.000 | ||||
| SA (mg/dL) | SA (mg/dL) | |||||
| > 52.35* vs ≤ 52.35* | 2.040 (1.370~3.037) | 0.000 | > 52.35* vs ≤ 52.35* | 5.246 (1.925~14.296) | 0.001 | |
| > 59# vs ≤ 59# | 2.061 (1.281~3.316) | 0.003 | > 59# vs ≤ 59# | 16.910 (6.744~42.398) | 0.000 | |
PCa: prostate cancer; BPH: benign prostate hyperplasia; LDH: lactate dehydrogenase; AKP: alkaline phosphatase; FIB: fibrinogen; PSA: prostate specific antigen; PV: prostate volume; HR: hazard ratio; Pathological grade: high (Gleason score > 7); low (Gleason score ≤ 7); SA*: cut-off value of SA levels regarding prediction of PCa; SA#: cut-off value of SA levels regarding prediction of bone metastases. p < 0.05 is considered as statistically significant; 95% CI: 95% confidence interval.