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. 2019 Feb;189(2):258–271. doi: 10.1016/j.ajpath.2018.10.007

Figure 5.

Figure 5

Depletion of hepatocyte integrin αvβ8 did not increase hepatocellular carcinoma (HCC) in mice, whereas human hepatocytes expressed integrin αvβ8 in acute and chronic liver disease. A: Schematic of mouse model of HCC. B: Representative images of livers from control and Itgb8flox/flox;Alb-Cre (β8-AlbCre) mice at harvest. C and D: Quantification of tumor number (C) and median tumor size (D) in control and β8-AlbCre mice at 40 weeks (horizontal bar indicates mean). E: Representative low- and high-power images of β8 integrin subunit immunostaining in uninjured human liver tissue, after acetaminophen overdose, or in cirrhosis. n = 16 and 14 control and β8-AlbCre mice (C and D); n = 5 uninjured human liver tissue samples (E); n = 5 acetaminophen overdose samples (E); n = 6 cirrhosis samples (E). Scale bars: 250 μm (top row; E); 100 μm (bottom row; E). DEN = diethylnitrosamine.