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. 2019 Feb;189(2):295–307. doi: 10.1016/j.ajpath.2018.10.019

Figure 3.

Figure 3

Increased neutrophil recruitment and decreased residual bacteria in mild traumatic brain injury (mTBI) mice in response to intratracheal administration of Pseudomonas aeruginosa (Psd). A: mTBI mice recruit more neutrophils to the airspace in response to a live infection, similar to the higher levels of neutrophils seen after administration of KC. B: Higher neutrophil numbers appear to lower the bacterial burden in the lungs of the mTBI mice. Blood collected from the vena cava upon sacrifice shows no detectable bacterial burden, suggesting the protein-level differences in mTBI mice at 48 hours does not predispose the mice to bacteremia when infected. Data are expressed as means ± SEM. n = 8 mTBI (A and B, BAL); n = 7 TT (A and B, BAL); n = 6 blood (B). ∗P < 0.05 versus TT (unpaired one-tailed t-test). BAL, bronchoalveolar lavage; BDL, below detection limit; CFU, colony-forming unit.