Skip to main content
. 2019 Feb;189(2):295–307. doi: 10.1016/j.ajpath.2018.10.019

Figure 5.

Figure 5

Representative heatmap of the gene sets up-regulated in mild traumatic brain injury (mTBI) versus blunt tail trauma (TT) within the KEGG classified Oxidative Phosphorylation set (red and blue = up-regulated and down-regulated compared with mean expression, respectively). A gene set that is significantly different between mTBI and TT with a P < 0.05 and FDR q < 0.25 suggests that the pathway or process could be changed as a result of the mTBI. A: Of the 94 significantly up-regulated gene sets in mTBI lungs, 20 are related to ATP synthesis and mitochondrial structure. B: Literature supports that brain injury causes a hypercatabolic state, as evidenced by the drop in weight of the mTBI group in the 2 days following trauma. Data are expressed as means ± SEM. n = 20 mTBI (B); n = 21 TT (B). ∗∗∗P < 0.001 versus mTBI at the corresponding time point (multiple unpaired two-tailed t-tests).