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. 2018 Dec 22;13(2):228–245. doi: 10.1002/1878-0261.12399

Figure 7.

Figure 7

Expression and prognostic value of OPN and FOXM1 in pancreatic cancer. (A) Representative images showing the absence of OPN or FOXM1 expression in normal pancreatic tissues and the presence of OPN expression in stromal cells or FOXM1 expression in tumor cells of pancreatic cancer tissues. The scale bar represents 400 μm for low magnification field and 100 μm for high magnification field. (B and C) The IHC scores of OPN (B) and FOXM1 (C) expression in normal pancreatic tissues (n = 25) and pancreatic cancer tissues (n = 75). (D and G) The expression of OPN (D) and FOXM1 (G) was upregulated in pancreatic cancer tissues compared to that in normal tissues. The red bar shows the tumor tissues, and the blue bar indicates the normal tissues. (E and H) The expression of OPN (E) and FOXM1 (H) was negatively correlated with pancreatic cancer patients’ OS. The red curve represents patients with a high level of OPN or FOXM1 expression (Top 25%), while the blue curve represents patients with a low level of OPN or FOXM1 expression (Bottom 25%). (F and I) The expression of OPN (F) and FOXM1 (I) was negatively correlated with pancreatic cancer patients’ DFS. The red curve represents patients with a high level of OPN or FOXM1 expression (top 25%), while the blue curve represents patients with a low level of OPN or FOXM1 expression (bottom 25%). These figures were derived from GEPIA. PAAD: Pancreatic adenocarcinoma. TPM: Transcripts per kilobase million. All data are shown as the mean ± SD of at least three independent experiments. Student's t‐test was performed to determine significance. *P < 0.05, **P < 0.01.