Figure 4.

Somatic variant detection in patients with metastatic cancer on samples isolated with the three different isolation platforms (QIAamp, Maxwell, and QIAsymphony). Somatic variant status had been assessed in patients’ primary and/or metastatic lesion as part of the standard of care. In all patients (N = 10), the known somatic variant was detected in plasma isolated from the three platforms. The ratios of the mutant copy number (A), wild‐type copy number (B), and variant allele frequency (VAF) measured in the Maxwell and QIAsymphony vs. QIAamp are shown (C). The dashed line (ratio of 1) resembles the situation when platforms have similar results. The Wilcoxon signed‐rank test was used to test the difference between the platforms.