Table 3.

Different amino acid changes and related cancer-driver genes detected in TMIT I and TMIT II bladder tumors.

TMIT I	Mutant gene (%)	Different amino acid changes	Related cancer-driver genes
I	RB1 (26.7%)	Retinoblastoma-associated protein A domain (373-573) Retinoblastoma-associated protein B domain (645 - 766) Rb C-terminal domain (768 - 927)	ZNF878,RGPD8,EEF1B2,KRTAP1-5,RXRA,GNA13,RAD51C, KRTAP4-11,PLK3
II	FGFR3 (25.3%)	Immunoglobulin I-set domain (260-356) Protein tyrosine kinase (472-748)	ZNF814,FGFR3,POTEM,KRAS,RGPD8, RHOA