Table 3.

Univariate Cox proportional hazards regression analysis for overall survival (OS) and disease-free survival(DFS) in patients with laryngeal squamous cell carcinoma(LSCC)

	OS		P	DFS		P
Characteristics	HR(95%CI)			HR(95%CI)
Age(y)			0.022*			0.432
<60	1			1
≥60	1.397(1.111-1.823)			1.197(0.611-1.323)
Gender			0.093			0.214
Male	2.011(0.912-3.447)			1.921(0.745-2.422)
Female	1			1
Smoking history			0.114			0.192
No	1			1
Yes	2.228(0.891-4.374)			1.765(0.889-3.018)
Drinking history			0.427			0.514
No	1			1
Yes	1.772(0.733-2.936)			1.234(0.533-2.109)
Tumor site			<0.001*			<0.001*
Supraglottic	2.101(1.506-2.930)			2.331(1.764-3.081)
Glottic&Subglottic	1			1
Tumor size			0.068			0.114
<2cm	1			1
≥2cm	1.781(0.996-2.578)			1.334(0.891-2.119)
T Stage			0.032*			0.019*
T1+2	1			1
T3+4	1.407(1.028-2.542)			1.604(1.112-2.315)
Lymph node metastasis			0.024*			0.033*
N0	1			1
N+	2.012(1.342-2.997)			1.387(1.118-2.009)
TNM stage			<0.001*			<0.001*
I+II	1			1
III-IV	2.932(1.412-4.976)			1.668(1.152-2.416)
Differentiation grade			0.012*			0.013*
Poor	1.667(1.289-2.178)			1.433(1.198-2.090)
Moderate & Well	1			1
AGR			<0.001*			<0.001*
<1.31	3.227(1.692-4.395)			3.512(2.330-5.294)
≥1.31	1			1
NLR			0.031*			<0.001*
<2.38	1			1
≥2.38	1.994(1.126-3.374)			2.295(1.312-4.015)
PLR			0.011*			0.024*
<116	1			1
≥116	1.815(1.160-2.841)			1.826(1.264-2.638)
LMR			0.019*			0.012*
<2.01	2.291(1.344-3.439)			2.283(1.433-3.635)
≥2.01	1			1

Abbreviations: HR hazard ratio, 95% CI 95% confidencel interval,AGR albumin/globulin ratio

NLR neutrophil/lymphocyte ratio, PLR platelet/lymphocyte ratio, LMR lymphocyte/monocyte ratio

* P < 0.05 considered as statistically significant.