Table 4.
Multivariate Cox proportional hazards regression analysis for overall survival (OS) and disease-free survival (DFS) in patients with laryngeal squamous cell carcinoma (LSCC)
| OS | P | DFS | P | ||||
|---|---|---|---|---|---|---|---|
| Characteristics | HR(95%CI) | HR(95%CI) | |||||
| Age(y) | 0.757 | - | |||||
| <60 | 1 | - | |||||
| ≥60 | 1.127(0.781-1.423) | ||||||
| Tumor site | 0.379 | 0.543 | |||||
| Supraglottic | 1.262(0.634-2.513) | 2.026(0.564-2.328) | |||||
| Glottic&Subglottic | 1 | 1 | |||||
| T Stage | 0.393 | 0.229 | |||||
| T1+2 | 1 | 1 | |||||
| T3+4 | 1.007(0.450-2.004) | 1.219(0.512-1.925) | |||||
| Lymph node metastasis | 0.021* | 0.048* | |||||
| N0 | 1 | 1 | |||||
| N+ | 1.512(1.332-2.294) | 1.561(1.322-2.976) | |||||
| TNM stage | <0.001* | <0.001* | |||||
| I+II | 1 | 1 | |||||
| III-IV | 2.014(1.397-2.904) | 2.403(1.768-3.266) | |||||
| Differentiation grade | 0.041* | 0.376 | |||||
| Poor | 1.327(1.008-2.178) | 1.234(0.582-1.992) | |||||
| Moderate & Well | 1 | 1 | |||||
| AGR | <0.001* | <0.001* | |||||
| <1.31 | 3.479(2.157-5.612) | 2.595(1.477-4.557) | |||||
| ≥1.31 | 1 | 1 | |||||
| NLR | 0.044* | 0.611 | |||||
| <2.38 | 1 | 1 | |||||
| ≥2.38 | 1.295(1.012-3.015) | 1.243(0.536-2.883) | |||||
| PLR | 0.021* | 0.089 | |||||
| <116 | 1 | 1 | |||||
| ≥116 | 1.621(1.083-2.427) | 1.546(0.946-2.527) | |||||
| LMR | 0.017* | 0.874 | |||||
| <2.01 | 1.898(1.191-2.540) | 1.104(0.446-1.950) | |||||
| ≥2.01 | 1 | 1 | |||||
Abbreviations: HR hazard ratio, 95% CI 95% confidence interval, AGR albumin/globulin ratio
NLR neutrophil/lymphocyte ratio, PLR platelet/lymphocyte ratio, LMR lymphocyte/monocyte ratio
* P < 0.05 considered as statistically significant.