Table 3.
Cox regression analyses for colorectal cancer-specific mortality
| Characteristics | Univariate analysis | Multivariate analysis# | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age<60 (vs. Age≥60) | 1.59 (0.99 to 2.58 ) | 0.060 | ||
| Male (vs. female) | 1.00 (0.62 to 1.60) | 0.100 | ||
| Tumor size≥4.5cm ( vs. size<4.5cm) | 1.70 (1.05 to 2.75) | 0.030 | 1.151(0.674 to 1.966) | 0.606 |
| Tumor location | ||||
| Distal colon vs. Proximal colon | 0.50 (0.26 to 0.98) | 0.040 | 0.661(0.332 to 1.313) | 0.237 |
| Rectum vs. Proximal colon | 1.39 (0.82 to 2.35) | 0.220 | ||
| Tumor stage III-IV (vs. stage I, II) | 3.24 (2.01 to 5.24) | 0.000 | 2.90 (1.78 to 4.75) | 0.000 |
| Grade (high vs. low ) | 2.69 (1.67 to 4.31) | 0.000 | 1.88 (1.14 to 3.11) | 0.014 |
| Chemotherapy(yes vs. no) | 1.23 (0.76 to 1.99) | 0.400 | ||
| YAP staining status | ||||
| C(+)N(+) | 1 (reference) | |||
| C(+)N(-) | 1.13 (0.44 to 2.89) | 0.800 | 1.02 (0.40 to 2.63) | 0.960 |
| C(-)N(+) | 1.21 (0.51 to 2.87) | 0.670 | 1.26 (0.53 to 3.01) | 0.604 |
| C(-)N(-) | 5.85 (3.48 to 9.85) | 0.000 | 3.93 (2.18 to 7.07) | 0.000 |
Abbreviation: HR: hazard ration; CI: Confidence interval.
#Tumor size, tumor location, tumor stage, tumor grade, and YAP staining status were included into multivariate Cox regression model.