Table 4.
Impact of prognostic factors for OS and CSS by multivariate analyses.
| Prognostic factor | overall survival | cancer-specific survival | ||||
|---|---|---|---|---|---|---|
| P value | HR | 95% CI | P value | HR | 95% CI | |
| Age | 0.00 | 1.55 | 1.36-1.78 | 0.00 | 1.44 | 1.20-1.73 |
| Race | 0.00 | 0.00 | ||||
| Caucasian | 1(reference) | 1(reference) | ||||
| Asian | 1.07 | 0.81-1.41 | 0.93 | 0.64-1.35 | ||
| African American | 1.47 | 1.24-1.75 | 1.40 | 1.12-1.75 | ||
| T classification | 0.00 | 0.00 | ||||
| T1 | 1(reference) | 1(reference) | ||||
| T2 | 1.67 | 1.23-2.25 | 2.10 | 1.29-3.41 | ||
| T3 | 2.34 | 1.72-3.18 | 2.99 | 1.84-4.86 | ||
| T4a | 3.32 | 2.43-4.54 | 4.46 | 2.73-7.29 | ||
| T4b | 3.21 | 2.28-4.53 | 4.19 | 2.49-7.05 | ||
| N classification | 0.01 | 0.00 | ||||
| N0 | 1(reference) | 1(reference) | ||||
| N1 | 1.05 | 0.86-1.29 | 1.16 | 0.85-1.57 | ||
| N2a | 1.25 | 0.87-1.78 | 1.53 | 0.97-2.43 | ||
| N2b | 1.12 | 0.93-1.35 | 1.30 | 1.00-1.69 | ||
| N2c | 1.17 | 0.95-1.43 | 1.64 | 1.25-2.17 | ||
| N3 | 1.82 | 1.33-2.48 | 2.44 | 1.65-3.61 | ||
| Tumor location | 0.00 | 0.02 | ||||
| Pyriform sinus | 1(reference) | 1(reference) | ||||
| Postcricoid region | 1.46 | 1.02-2.11 | 1.57 | 0.94-2.64 | ||
| Aryepiglottic fold, hypopharyngeal | 1.03 | 0.78-1.36 | 0.86 | 0.57-1.29 | ||
| Posterior wall of hypopharynx | 1.37 | 1.07-1.76 | 1.51 | 1.08-2.10 | ||
| Overlapping lesion of hypopharynx | 1.15 | 0.77-1.71 | 1.31 | 0.80-2.15 | ||
| Hypopharynx, NOS | 1.29 | 1.10-1.51 | 1.30 | 1.06-1.60 | ||
| Surgery therapy | 0.00 | 1.45 | 1.23-1.70 | 0.00 | 1.51 | 1.19-1.93 |
| Distant metastases | 0.00 | 0.00 | ||||
| No | 1(reference) | 1(reference) | ||||
| Single | 2.24 | 1.71-2.93 | 2.36 | 1.68-3.31 | ||
| Multiple | 2.74 | 1.60-4.70 | 2.87 | 1.59-5.16 | ||
Abbreviations: CI = confidence interval; HR = hazard ratio; P values were calculated using an adjusted Cox proportional-hazards model