Table 2.
Univariate and multivariate Cox proportional hazard regression analysis of clinicopathologic features for biochemical recurrence
| Factors | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | ||
| Age (years) | 1.083 | 1.001-1.171 | 0.048 | 1.084 | 0.968-1.172 | 0.064 | |
| BMI (kg/m2) | 1.008 | 0.841-1.208 | 0.933 | - | - | - | |
| Preoperative PSA (ng/mL) | 1.027 | 1.013-1.042 | <0.001 | 1.022 | 1.006-1.038 | 0.006 | |
| Prostate volume (mL) | 0.998 | 0.963-1.035 | 0.927 | - | - | - | |
| Pathologic T stage | |||||||
| 2 | Reference | - | - | - | |||
| 3a | 3.991 | 1.205-13.217 | 0.023 | - | - | - | |
| 3b | 7.258 | 2.417-21.797 | <0.001 | - | - | - | |
| Pathologic Gleason score | |||||||
| ≤ 6 | Reference | - | - | - | |||
| 7 (3+4) | 1.246 | 0.129-12.072 | 0.850 | - | - | - | |
| 7 (4+3) | 4.577 | 0.565-37.051 | 0.154 | - | - | - | |
| ≥ 8 | 8.162 | 0.979-68.048 | 0.052 | - | - | - | |
| Positive surgical margin | 4.053 | 1.516-10.836 | 0.005 | 3.039 | 1.099-8.401 | 0.032 | |
| Lymphovascular invasion | 1.372 | 0.182-10.328 | 0.759 | - | - | - | |
| Perineural invasion | 4.086 | 0.939-17.781 | 0.061 | - | - | - | |
| High FOXM1 expression | 10.524 | 1.400-79.087 | 0.022 | 8.819 | 1.166-66.711 | 0.035 | |
HR, hazard ratio; CI, confidence interval; BMI, body mass index; PSA, prostate-specific antigen