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. 2019 Jan 1;10(3):611–619. doi: 10.7150/jca.28780

Table 2.

Assessment of diagnostic accuracy and heterogeneity in subgroup analysis.

Subgroups No. of studies Pooled sensitivity (95% CI) I2 (%) sensitivity Pooled specificity (95% CI) I2 (%) specificity Pooled positive LR (95% CI) I2 (%) positive LR Pooled negative LR (95% CI) I2 (%) negative LR Pooled DOR I2 (%) DOR AUC
All studies 21 0.83 (0.76-0.87) 87.36 0.84 (0.77-0.89) 91.42 5.11(3.57-7.31) 89.72 0.21 (0.15-0.28) 85.82 24.57 (14.67-41.17) 100.00 0.90 (0.87-0.92)
Sample size
≤200 13 0.81 (0.74-0.87) 76.12 0.84 (0.75-0.90) 81.28 5.06 (3.24-7.93) 70.55 0.22 (0.16-0.31) 72.72 22.71 (12.45-41.41) 99.62 0.89 (0.86-0.92)
>200 8 0.84 (0.72-0.91) 93.49 0.83 (0.71-0.91) 95.72 5.05 (2.84-8.98) 94.69 0.19 (0.11-0.35) 92.82 26.00 (10.57-63.97) 100.00 0.90 (0.88-0.93)
Specimen source
Tissue 8 0.86 (0.74-0.93) 92.51 0.78 (0.64-0.88) 93.95 4.00 (2.30-6.95) 92.12 0.18 (0.09-0.35) 92.40 22.42 (8.20-61.28) 100.00 0.89 (0.86-0.92)
Blood 13 0.80 (0.73-0.85) 81.05 0.87 (0.79-0.91) 84.14 5.91 (3.82-9.14) 78.40 0.23 (0.17-0.31) 80.33 25.26 (14.34-44.50) 100.00 0.89 (0.86-0.92)

CI: confidence interval; LR: likelihood ratio; DOR: diagnostic odds ratio; AUC: area under the curve.