Table 2.
Assessment of diagnostic accuracy and heterogeneity in subgroup analysis.
| Subgroups | No. of studies | Pooled sensitivity (95% CI) | I2 (%) sensitivity | Pooled specificity (95% CI) | I2 (%) specificity | Pooled positive LR (95% CI) | I2 (%) positive LR | Pooled negative LR (95% CI) | I2 (%) negative LR | Pooled DOR | I2 (%) DOR | AUC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All studies | 21 | 0.83 (0.76-0.87) | 87.36 | 0.84 (0.77-0.89) | 91.42 | 5.11(3.57-7.31) | 89.72 | 0.21 (0.15-0.28) | 85.82 | 24.57 (14.67-41.17) | 100.00 | 0.90 (0.87-0.92) |
| Sample size | ||||||||||||
| ≤200 | 13 | 0.81 (0.74-0.87) | 76.12 | 0.84 (0.75-0.90) | 81.28 | 5.06 (3.24-7.93) | 70.55 | 0.22 (0.16-0.31) | 72.72 | 22.71 (12.45-41.41) | 99.62 | 0.89 (0.86-0.92) |
| >200 | 8 | 0.84 (0.72-0.91) | 93.49 | 0.83 (0.71-0.91) | 95.72 | 5.05 (2.84-8.98) | 94.69 | 0.19 (0.11-0.35) | 92.82 | 26.00 (10.57-63.97) | 100.00 | 0.90 (0.88-0.93) |
| Specimen source | ||||||||||||
| Tissue | 8 | 0.86 (0.74-0.93) | 92.51 | 0.78 (0.64-0.88) | 93.95 | 4.00 (2.30-6.95) | 92.12 | 0.18 (0.09-0.35) | 92.40 | 22.42 (8.20-61.28) | 100.00 | 0.89 (0.86-0.92) |
| Blood | 13 | 0.80 (0.73-0.85) | 81.05 | 0.87 (0.79-0.91) | 84.14 | 5.91 (3.82-9.14) | 78.40 | 0.23 (0.17-0.31) | 80.33 | 25.26 (14.34-44.50) | 100.00 | 0.89 (0.86-0.92) |
CI: confidence interval; LR: likelihood ratio; DOR: diagnostic odds ratio; AUC: area under the curve.