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. 2019 Feb 1;10:104–111. doi: 10.1016/j.reth.2018.12.002

Fig. 4.

Fig. 4

Blocking effects of class Ia, Ib and Ic antiarrhythmic agents on INa. Top: Representative original traces of INa recorded in the absence and presence of one of the three class I antiarrhythmic agents at indicated concentrations. INa was elicited by a train of 20-ms test pulses to −20 mV from a HP of −90 mV at 0.2 Hz; steady-state currents determined at the 20th pulses are shown. Bottom: Concentration-dependent inhibitory effects of the three class I antiarrhythmic agents on INa (n = 7–10). The curves are fits by Eq. (1) with the mean IC50 and Hill coefficient values given in the text.