Table 3.
Demographics, pathological and MRI characteristics of included donors.
| ID | Case 1 | Case 2 | Case 3 | Case 4 | Case 5 | Mean ± SD |
|---|---|---|---|---|---|---|
| Gender | M | F | F | F | F | 1 M/4F |
| Age (y) | 68 | 71 | 72 | 77 | 59 | 69.4 ± 5.9 |
| PMI (h:m) | 8:40 | 6:50 | 7:20 | 4:30 | 8:10 | 7:02 ± 1:34 |
| pH of CSF | 6.12 | 6.87 | n/a | 6.5 | 6.08 | 6.39 ± 0.32 |
| Pathological classification “ABC score” | A1 B1 C0 | A1 B1 C0 | A0 B0 C0 | A1 B1 C0 | A0 B0 C0 | – |
| Thal phase | 2 | 2 | 0 | 2 | 0 | – |
| Braak NFT | 1 | 0–1 | 0 | 2 | 0 | – |
| Braak a-syn | 0 | 0 | 0 | 0 | 0 | – |
| TDP-43 | 0 | 0 | 0 | 0 | 0 | – |
| CAA | 0 | 0 | 0 | 0 | 0 | – |
| APOE-4 | E3/E4 | E3/E4 | E3/E3 | E3/E3 | E3/E3 | – |
| MTA R/L | 0/0 | 0/1 | 0/0 | 1/2 | 0/0 | – |
| GCA | 0 | 1 | 0 | 1 | 1 | – |
| Fazekas | 0 | 2 | 1 | 2 | 2 | – |
| lacunes | 0 | 0 | 0 | 0 | 0 | – |
| BG lacunes | 0 | 0 | 0 | 0 | 0 | – |
| Infarcts | 0 | 0 | 0 | 0 | 0 | – |
| NBV (L)a | 1.61 | 1.48 | 1.51 | 1.50 | 1.46 | 1.51 ± 0.05 |
| NWMV (L)a | 0.76 | 0.71 | 0.72 | 0.71 | 0.68 | 0.72 ± 0.03 |
| NGMV (L)a | 0.85 | 0.77 | 0.80 | 0.78 | 0.78 | 0.80 ± 0.03 |
| Hippocampus right (ml)b | 5.31 | 4.85 | 6.52 | 5.20 | 5.60 | 5.50 ± 0.57 |
| Hippocampus left (ml)b | 5.06 | 5.21 | 6.35 | 4.24 | 5.67 | 5.31 ± 0.70 |
M = male, F = female, PMI = post-mortem interval, CSF = cerebrospinal fluid NBV = normalized brain volume, ABC score = score for Aβ deposition (A), for Braak stage of neurofibrillary degeneration (B) and neuritic plaque score (C), NFT = neurofibilary tangles, TDP = TAR DNA-binding protein, CAA = cerebral amyloid angiopathy, APOE = Apolipoprotein E, GCA = global cortical atrophy,BG = basal ganglia, NWMV = normalized white matter volume in litres (L), NGMV = normalized gray matter volume. n/a = not available.
a
Normalized volumes obtained with SIENAX.
b
Normalized volumes obtained with FIRST.