Table 1.
Clinical and laboratory findings between patient groups based on GFR and ISKDC classification.
| Factors | All patients | Renal failure | Chronic renal failure | ISKDC classification | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| (n=49) | ECr c (n=17) | Non-ECr (n=32) | P | CRF d (n=13) | Non-CRF (n=36) | P | Class I-II (n=25) | Class III–IV (n=24) | P | |
| Mean±SD/ n (%) | Mean±SD/ n (%) | Mean±SD/ n (%) | Mean±SD/ n (%) | Mean±SD/ n (%) | Mean±SD/ n (%) | Mean±SD/ n (%) | ||||
| Baseline characteristics | ||||||||||
| Age (years) | 39.6±19.8 | 54.2±21.3 | 31.8±14.0 | <0.001 | 64.2±16.5 | 30.6±11.8 | <0.001 | 34.0±10.8 | 45.4±25.1 | 0.047 |
| Sex (Male:Female) | (26:23) | (11:6) | (15:17) | 0.234 | (5:8) | (21:15) | 0.218 | (14:11) | (12:12) | 0.674 |
| BMI (kg/m2) | 21.7±3.8 | 23.9±3.8 | 20.5±3.3 | 0.003 | 23.1±3.3 | 21.1±3.9 | 0.107 | 22.4±4.3 | 20.9±3.2 | 0.178 |
| Clinical presentations | ||||||||||
| Arthralgia | 7 (14.3) | 2 (11.8) | 5 (15.6) | 0.999 | 1 (7.7) | 6 (16.7) | 0.658 | 4 (16.0) | 3 (12.5) | 0.999 |
| Abdominal pain | 6 (18.4) | 3 (17.6) | 6 (18.8) | 0.999 | 1 (7.7) | 8 (22.2) | 0.412 | 5 (20.0) | 4 (16.7) | 0.999 |
| Melena | 3 (6.1) | 2 (11.8) | 1 (3.1) | 0.273 | 1 (7.7) | 2 (5.6) | 0.999 | 2 (8.0) | 1 (4.2) | 0.999 |
| Gross hematuria | 16 (32.7) | 6 (35.3) | 10 (313) | 0.774 | 4 (30.8) | 12 (33.3) | 0.999 | 10 (40.0) | 6 (25.0) | 0.263 |
| Laboratory findings | ||||||||||
| GFRa | 90.3±39.5 | 57.7±34.8 | 108.2±29.5 | <0.001 | 38.8±14.4 | 109.4±26.4 | 80.9±45.0 | 99.6±31.4 | 0.104 | |
| Creatinine (mg/dl) | 1.0±0.7 | 1.6±1.0 | 0.7±0.2 | 1.7±1.1 | 0.8±0.2 | 0.008 | 1.2±1.0 | 0.8±0.3 | 0.095 | |
| Albumin (mg/dl) | 4.1±1.0 | 3.6±1.0 | 4.4±0.9 | 0.003 | 3.5±0.9 | 4.3±0.9 | 0.006 | 4.1±1.3 | 4.2±0.5 | 0.677 |
| Hypoalbuminemia (Albumin < 3.0 mg/dl) | 7 (14.3) | 6 (35.3) | 1 (3.1) | 0.005 | 4 (30.8) | 3 (8.3) | 0.070 | 1 (4.0) | 6 (25.0) | 0.049 |
| 24hr proteinuria (g/day) | 2114.7±2161.6 | 2,706.1±2,849.3 | 1,892.1±1,803.0 | 0.358 | 2,273.6±2,971.1 | 2,086.7±1,776.9 | 0.864 | 2,751.6±2,525.2 | 1,494.5±1,521.8 | 0.115 |
| Nephrotic syndrome range of proteinuriab | 11 (37.9) | 4(44.4) | 7 (35.0) | 0.694 | 3 (33.3) | 8 (40.0) | 0.999 | 4 (28.6) | 7 (46.7) | 0.316 |
aGFR was estimated using the Modification of Diet in Renal Disease study equation.
bNephrotic syndrome range of proteinuria is above 2.5 g/day in total urine.
cDefinition of elevation of creatinine (ECr) is the status of high creatinine ≥ 1.0 mg/dl.
dDefinition of chronic renal failure (CRF) is the status of low glomerular filtration rate (GFR), which is below 60 ml/min/1.73 m2 for more than 3 months.
BMI, body mass index; GFR, glomerular filtration rate; ISKDC, International Study of Kidney Disease in Children.