Table 2.
Light microscopy and immunofluorescence findings for patient groups based on GFR and ISKDC classification.
| Factors | Renal failure | Chronic renal failure | ISKDC classification | ||||||
|---|---|---|---|---|---|---|---|---|---|
| ECr (n=17) | Non-ECr (n=32) | P a | CRF (n=13) | Non-CRF (n=36) | P a | Class I-II (n=25) | Class III–IV (n=24) | P a | |
| Mean±SD or n (%) | Mean±SD or n (%) | Mean±SD or n (%) | Mean±SD or n (%) | Mean±SD or n (%) | Mean±SD or n (%) | ||||
| Light microscopy studies | |||||||||
| Number of glomeruli evaluated | 13.8±6.6 | 19.5±9.6 | 0.037 | 13.1±6.7 | 19.1±9.3 | 0.046 | 17.0±8.1 | 18.1±10.0 | 0.696 |
| % Glomeruli involved by crescent | 13.6±14.6 | 4.7±8.1 | 0.036 | 13.6±13.5 | 5.7±10.0 | 0.037 | 0.0±0.0 | 15.8±11.8 | <0.001 |
| Presence of sclerotic glomeruli [crescent] | 10 (62.5) | 10 (32.3) | 0.047 | 9 (75.0) | 11 (31.4) | 0.008 | 0 (0.0) | 20 (87.0) | <0.001 |
| Presence of endocapillary proliferation | 2 (11.8) | 2 (6.3) | 0.602 | 1 (7.7) | 3 (8.3) | 0.999 | 2 (8.0) | 2 (8.3) | 0.999 |
| Immunofluorescence studies | |||||||||
| IgG | 0.4±0.7 | 0.3±0.5 | 0.564 | 0.5±0.7 | 0.3±0.5 | 0.358 | 0.4±0.5 | 0.3±0.6 | 0.590 |
| IgA | 1.8±0.9 | 1.6±0.8 | 0.340 | 1.6±0.9 | 1.7±0.8 | 0.614 | 1.8±0.8 | 1.5±0.8 | 0.259 |
| IgM | 0.3±0.3 | 0.2±0.2 | 0.120 | 0.3±0.3 | 0.2±0.2 | 0.024 | 0.2±0.2 | 0.3±0.3 | 0.245 |
| C3 | 0.7±0.7 | 0.5±0.4 | 0.358 | 0.7±0.7 | 0.6±0.5 | 0.626 | 0.6±0.4 | 0.6±0.6 | 0.671 |
| C4 | 0.0±0.0 | 0.0±0.1 | 0.083 | 0.0±0.1 | 0.0±0.1 | 0.788 | 0.0±0.1 | 0.0±0.1 | 0.585 |
| C1q | 0.0±0.0 | 0.0±0.1 | 0.161 | 0.0±0.0 | 0.0±0.1 | 0.396 | 0.0±0.1 | 0.0±0.0 | 0.161 |
| Fibrinogen | 1.4±1.0 | 1.1±0.8 | 0.211 | 1.3±0.8 | 1.2±0.8 | 0.718 | 1.1±0.8 | 1.3±0.9 | 0.424 |
aChi-square test, Mantel-Haenszel Chi-square test, or Fischer exact test for categorical variables; P-value < 0.05 was considered statistically significant.
GFR, glomerular filtration rate; ISKDC, International Study of Kidney Disease in Children.