Table 3.
Comparison of M1 and M2 macrophage counts according to patient groups based on GFR and ISKDC classification.
| Factors | ECr a | Non-ECr a | P c | CRF b | Non-CRF b | P c | Class I-II | Class III-IV | P c | Crescents | No crescents | P c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (n=17) Mean±SD | (n=32) Mean±SD | (n=13) Mean±SD | (n=36) Mean±SD | (n=25) Mean±SD | (n=24) Mean±SD | (n=20) Mean±SD | (n=27) Mean±SD | |||||
| Glomeruli | ||||||||||||
| M1 | 2.3±4.4 | 0.3±0.8 | 0.088 | 2.5±5.0 | 0.4±0.9 | 0.156 | 0.4±0.9 | 1.7±3.8 | 0.115 | 2.0±4.1 | 0.4±0.8 | 0.099 |
| M2 | 8.7±14.7 | 4.1±9.1 | 0.176 | 9.7±16.6 | 4.2±8.7 | 0.274 | 3.4±10.3 | 8.0±12.3 | 0.164 | 9.2±13.1 | 3.4±9.9 | 0.094 |
| Tubulointerstitium | ||||||||||||
| M1 | 1.5±2.8 | 0.1±0.2 | 0.055 | 0.9±1.5 | 0.5±1.9 | 0.468 | 0.2±0.4 | 1.0±2.5 | 0.118 | 1.2±2.7 | 0.2±0.3 | 0.089 |
| M2 | 81.1±44.7 | 37.4±24.0 | 0.001 | 86.4±33.9 | 40.4±32.6 | <0.001 | 35.8±24.5 | 70.1±42.9 | 0.002 | 73.7±41.8 | 35.7±23.3 | 0.001 |
aDefinition of elevation of creatinine (ECr) is the status of high creatinine ≥1.0 mg/dl.
bDefinition of chronic renal failure (CRF) is the status of low GFR, which is below 60 ml/min/1.73 m2 for more than 3 months.
cIndependent two-sample t-test for continuous variables; P-value <0.05 was considered statistically significant.
GFR, glomerular filtration rate; ISKDC, International Study of Kidney Disease in Children.