Table 1.

Association between ITGBL1 expression and clinicopathological factors

Variables	Testing cohort N (%)			Validation cohort N (%)
	ITGBL1 level			ITGBL1 level
	Low	High	P value	Low	High	P value
	N=130	N=71		N=256	N=212
Gender
Male	61	29	0.41	162	113	0.03
Female	69	42		94	99
Age
<65	80	45	0.88	114	81	0.19
≥65	50	26		142	131
Location
Colon	65	36	0.92	160	131	0.88
Rectum	65	35		96	81
Histology
Differentiated	119	68	0.39	239	191	0.23
Undifferentiated	11	3		17	21
Tumor size (mm)
≤45	81	29	<0.01	151	72	<0.0001
>45	49	42		91	137
Unavailable	0	0		14	3
T stage
T1,T2	37	7	<0.01	68	24	<0.0001
T3,T4	93	64		188	188
Lymphovascular invasion
Absent	55	11	<0.0001	41	16	<0.01
Present	75	60		213	196
Unavailable	0	0		2	0
Lymph node Metastasis
Absent	69	21	0.001	137	113	0.96
Present	61	50		119	99
Distant metastasis
Absent	120	57	0.02	224	163	<0.01
Present	10	14		32	49
Stage
I, II	67	18	<0.001	132	103	0.52
III, IV	63	53		124	109
Preoperative CEA (ng/ml)
<5	88	39	0.07	156	114	0.12
5≤	42	32		100	98