Table 2.
Assessment of high risks associated with disease severity among 202 acute sporadic HEV inpatients from the east- coast area of Zhejiang Province, China, 2004–2017
| Valuable | Non-severe cases (n = 100) | Severe cases (n = 102) | OR (95% CI) | P value |
|---|---|---|---|---|
| Demographic characteristics | ||||
| Age range (years) | 23–80 | 24–83 | / | |
| Mean age ± SD (years) | 50.63 ± 12.51 | 51.91 ± 13.81 | / | 0.49d |
| Sex ratio (male/female) | 2.33 (70/30) | 7.50 (90/12) | 0.311 (0.149–0.651) | < 0.01a |
| Educational level (<college) (%, n) | 87.00 (87/100) | 92.16 (94/102) | 0.570 (0.225–1.440) | 0.23a |
| Smoker (%, n) | 20.00% (20/100) | 41.18% (42/102) | 2.800 (1.493–5.252) | < 0.01a |
| Alcohol user (%, n) | 28.00% (28/100) | 49.02% (50/102) | 2.473 (1.379–4.434) | < 0.01a |
| History of blood transfusion (%, n) | 4.00% (4/100) | 4.90% (5/102) | 1.237 (0.322–4.747) | 1.00b |
| Hepatoxic medication (%, n) | 11.00% (11/100) | 13.73% (14/102) | 1.287 (0.554–2.990) | 0.56a |
| Chronic liver diseases (%, n) | 36.00% (36/100) | 51.96% (53/102) | 1.923 (1.094–3.378) | 0.02a |
| Hepatitis A | 1.00% (1/100) | 0 (0/102) | 0.990 (0.971–1.010) | 0.50b |
| Hepatitis B | 24.00% (24/100) | 35.29% (36/102) | 1.727 (0.936–3.188) | 0.08a |
| Hepatitis C | 1.00% (1/100) | 0 (0/102) | 0.990 (0.971–1.010) | 0.50b |
| Liver cirrhosis | 4.00% (4/100) | 9.80% (10/102) | 2.609 (0.790–8.612) | 0.10a |
| Fatty liver disease | 4.00% (4/100) | 7.84% (8/102) | 2.043 (0.595–7.012) | 0.25a |
| Alcoholic liver disease | 9.00% (9/100) | 19.61% (20/102) | 2.466 (1.063–5.720) | 0.03a |
| Hepatic carcinoma | 1.00% (1/100) | 2.94% (3/102) | 3.000 (0.307–29.337) | 0.62b |
| Drug-induced hepatitis | 1.00% (1/100) | 0.98% (1/102) | 0.980 (0.060–15.889) | 1.00b |
| Chronic nonliver comorbidities (%, n) | / | 0.75c | ||
| No comorbidities | 56.00% (56/100) | 60.78% (62/102) | / | |
| 1 comorbidity | 27.00% (27/100) | 23.53% (24/102) | / | |
| 2 comorbidities | 12.00% (12/100) | 8.82% (9/102) | / | |
| ≥ 3 comorbidities | 5.00% (5/100) | 6.86% (7/102) | / | |
| Disease progression | ||||
| Median days from onset to consultation | 6 (0–39) | 6 (0–24) | / | 0.93c |
| Median days from onset to admission | 7 (1–49) | 7 (2–38) | / | 0.12c |
| Median days from onset to confirmation | 11.5 (4–54) | 11 (4–43) | / | 0.75c |
| Median days from onset to discharge | 27 (9–71) | 36.5 (14–111) | / | < 0.001c |
| Days hospitalized | 18 (5–46) | 26 (7–108) | / | < 0.001c |
Notes: Non-severe cases denote mild and moderate cases; SD standard deviation, a = Chi-square test; b = Fisher test; c = Non-parametric test; and d = T test in P value column; “/” denotes not available