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. 2019 Feb 4;26:14. doi: 10.1186/s12929-019-0507-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Knockdown of NFBD1 enhances NPC cells to be sensitive to PARP inhibitor olaparib. (a) Cells were plated at low density, irradiated and colonies counted after 10–14 days. Results are normalized for effects of NFBD1 and fitted to a standard linear quadratic model. (b) NFBD1 knockdown enhanced the cytotoxicity to olaparib in a dose-dependent manner. shControl and shNFBD1 cells were treated with various concentrations of olaparib for 24 h. Cell viability was measured using MTS assays. The data are presented as the mean ± SD of triplicate determinations. IC50 values are presented as the mean ± SD of triplicate determinations. **P < 0.01 and ***P < 0.001