Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Feb 4;26:14. doi: 10.1186/s12929-019-0507-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 6 — Loss of NFBD1 causes HRR deficiency (a) Cells stably transfected with a DR-GFP reporter construct express GFP were transfection of I-SceI endonuclease expression vector. Extent of HR was analyzed by FCM 48 h after transfection. (b and c) Inhibition of NFBD1 resulted in defective BRCA1 and BRCA2 foci formation after olaparib exposure. (d) Silencing NFBD1 disrupts olaparib-induced BRCA1 interaction with γ-H2AX. (e) Cells were treated 4 μg/ml olaparib for 24 h, and subjected to western blotting analysis with indicated antibodies. Representative blots were shown with β-actin as loading control